بررسی تأثیر رژیمهای غذایی غنی از منیزیم بر روی غلظت خونی کلسترول و تری‌گلیسرید در خرگوش

ABSTRACT Coronary artety disease (CAD) is the leading cause of death in most developed countries, Cardiovascular disease (CVD) is the most common cause of death in Iran. The data from the Framingham heart study and other iarge scale epidemiologic studies have identified major risk factors associated with CAD, demonstrating the adverse effects of increased total and low-density lipoprotein- cholestrol levels and the protective effect of highdensity lipoprotein cholestrol. In this study, the effect of magnesium- enriched diets on the various plasma levels of cholestrol has been investigated. 40 rabbits divided in 4 groups were fed as follows: 1. Normal diet 2. Normak diet + 1. 67% Mg (OH)2 3. Normal diet + 2% cholestrol 4. Normal diet + 2% cholestrol + 1.67/ Mg (OH)2   The levels of plasma lipids were measured at the beginning and at the end of 4th and 8th weeks of the study. The results obtained according to ANOVA show that Mg can decrease total cholestrol and LDL-cholestrol significantly in the rabbits fed with high cholestrol diets (P 0.05) but this effect is not seen in both groups taking either normal or high cholstrol diets and increases HDL-cholestrol (P 0.05). The importance of HDL-cholestrol in the protection of cardiovascular system and the related effect of Mg in this field necessitates further study on animal models to evaluate the possibility of indication of Mg- enriched diets in man.